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KMID : 1002120040010020050
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Journal of Korean Sleep Research Society
2004 Volume.1 No. 2 p.50 ~ p.53
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Symptomatic Narcolepsy associated with Lesion of Hypothalamus in Multiple Sclerosis
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Shin Won-Chul
Kim Dae-Sung
Shin Dong-Jin
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Abstract
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We report a rare case of multiple sclerosis(MS) with hypothalamic lesions. A 33-year-old man with long history of MS was admitted with acute hypersomnia. He did not have sleep paralysis, hypnagogic hallucination, or cataplexy. Brain MRI showed a new plaque in both hypothalamus and thalamus. Polysomnography revealed severe obstructive sleep apnea syndrome. On the multiple sleep latency test(MSLT), average sleep latency was 54 seconds and there were noted 3 SOREM(Sleep Onset REM) on 5 trial. His sleepiness improved following treatment with steroid and methylphenidate. 4 month later, follow-up polysomnography and MSLT were performed. There were no differences in API during full night polysomnography but no SOREM in MSLT was observed.
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KEYWORD
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narcolepsy, multiple sclerosis, polysomnography, multiple sleep latency test(MSLT)
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